MS in Bio-Analytical Toxicology

The Graduate Division of the FHS offers Master of Science (M.S.) degrees. The main areas of instruction are in Biotechnology, Bio-analytical Toxicology and Optics and Optometry. The Biotechnology program has two tracks: DNA Technologies and Forensic Science. Offered courses include basic biology and chemistry to advanced clinical molecular genetics band Forensics.

The Ministry of Higher Education authorized the American University of Science and Technology to establish the Faculty of Health Sciences (FHS) in accordance with the file presented to the Council of Higher Education as per decree number 677 dated August 30, 2007. This was later followed by the permit to start teaching in the majors of Clinical Laboratory Science (CLS) and Optics and Optometry (OAO).

 

 
 
TOTAL REQUIRED CREDITS FOR GRADUATION (36 credits)
CORE REQUIREMENTS (9 credits)
CODE DESCRIPTION PREREQUISITE CR.
CLS 570 Bioorganic Chemistry NONE
3
CLS 571 Advanced Instrumental Chemistry NONE
3
CLS 575 Pharmacology and Medicinal Chemistry NONE
3
GRADUATION REQUIREMENTS (6 credits)
CODE DESCRIPTION PREREQUISITE CR.
CLS 598 Master's Thesis II Approval of Advisor
3
CLS 599 Master's Thesis Approval of Advisor
6
MAJOR REQUIREMENTS: (21 credits)
CODE DESCRIPTION PREREQUISITE CR.
CLS 529 Quality Assurance NONE
3
CLS 565 Biostatistics and Epidemiology NONE
3
CLS 573 Sample Preparation NONE
3
CLS 579 Applied Toxicology NONE
1
CLS 580 Seminars in Biotechnology NONE
1
CLS 582 Forensic Chemistry and Toxicology NONE
3
CLS 588 Method Validation NONE
3
CLS 590 Writing a Research Proposal Approval of advisor
1
CLS 593 Pharmaceutical Quality Control NONE
3
CLS579L Applied Toxicology Laboratory NONE
1
CLS583L Forensic Chemistry Laboratory NONE
1
CLS585L Forensic Toxicology Laboratory NONE
3
Course Descriptions
CLS 570
Bioorganic Chemistry
This is an advanced course designed to provide biochemical principles and applications pertinent to cell function and membrane structure. Research-related biochemical methodologies of macromolecules identification and analysis will be emphasized.
Prerequisite: NONE
CLS 571
Advanced Instrumental Chemistry
This course triggers in-depth understanding of current methods used in advanced instrumental chemistry, their uses, strengths and limitations. Students will acquire advanced theoretical knowledge of analytical instruments used in chemical and biochemical laboratories including spectroscopic techniques, mass spectrometry, ion mobility, high performance liquid chromatography, gas chromatography and computational modeling all of which methods are used in the identification of sample composition and structure.
Prerequisite: NONE
CLS 575
Pharmacology and Medicinal Chemistry
This course combines an in-depth understanding of pharmacology with a condensed overview of medicinal chemistry and its applications. The pharmacology part will address the use, effect, and interaction of a drug in the organism with an emphasis on major action, side effects, toxic symptoms and linkage to chemical configuration of the drug molecule. The Medicinal Chemistry part of the course will describe the alteration of chemical properties and functional groups in drugs to better their availability, absorption, metabolism, pharmacokinetics and duration of action.
Prerequisite: NONE
CLS 598
Master's Thesis II
Each graduate student is required to submit, under the supervision of a faculty member, a research proposal in a grant application form following NIH guidelines in related field of study. Students will present and defend their proposals.
Prerequisite: Approval of Advisor
CLS 599
Master's Thesis
Students conduct laboratory research under the guidance of a faculty member in the faculty of Health Sciences in a selected area. Students should submit a written report and present and defend their projects.
Prerequisite: Approval of Advisor
CLS 529
Quality Assurance
In both pharmacology and toxicology, an effective Quality Assurance is crucial to preserving the integrity of the data generated in the laboratory and to be released in the form of raw, processed and finished materials. This course provides hands-on practice of Good Laboratory Practices (GLP) and Good Manufacturing Practices (GMP) that must be adopted to produce materials in compliance with international standards. Major aspects of QA will be addressed, among which the identification of critical sources of variability and their control, sampling systems, regulatory requirements for lab operations, prediction of product quality, and the methodology for the measurement of manufacturing quality.
Prerequisite: NONE
CLS 565
Biostatistics and Epidemiology

This is advanced course in the applications of biostatistics and epidemiology into research projects. The goal is to present latest research statistical methodology useful in analyzing biomedical data. The course covers both theory and applications in the form of problem solving and applications on current research projects in Biotechnology and Bio-analytical toxicology.

Prerequisite: NONE
CLS 573
Sample Preparation
This short course is designed to provide theoretical insight into the different toxicology and pharmacology sample types, their preparation schemes, sizes, storage methods and handling. Course also covers the statistical requirements in sampling planning and incoming materials evaluation.
Prerequisite: NONE
CLS 579
Applied Toxicology
This course will drive students through the concepts of drug toxicokinetics and toxicodynamic activities on public health. Course will discuss the adverse effects of drugs on living systems (cells, tissues, organs, and organisms) with an overview of drug distribution, cellular penetration, metabolic conversions, and excretion. Aspects of drugs adverse effects will be addressed in the context of specific toxicology-related diseases and will include an understanding of the environmental factors that can enhance drug toxicity.
Prerequisite: NONE
CLS 580
Seminars in Biotechnology
Includes review and scientific critique of literature, overview of research design and style of scientific papers related to Biotechnology. Students will present papers related to current literature on a weekly basis. In addition, students will attend a minimum of seven seminars by visiting scientists and submit a final report listing the date, title and name of the speaker along with a one paragraph summary of each seminar.
Prerequisite: NONE
CLS 582
Forensic Chemistry and Toxicology
This course addresses implications of toxicological analyses of drugs and chemical materials found at a crime scene or in the bodies of victims and crime suspects. Step-wise approach of drug characterization and identification will be described in depth. Students will make an extensive use of their theoretical learning of analytical chemistry as they will know how and when to use various separation techniques (gas chromatography, HPLC, and thin-layer chromatography) on drugs identified at a crime scene and how Mass spectrometry can be crucial at providing evidence in court. Course triggers the understanding of drug quantification, means of administration, toxicity and poisoning effects, which may altogether lead to death.
Prerequisite: NONE
CLS 588
Method Validation
Students will be provided with fundamental knowledge of pharmaceutical manufacturing processes with emphasis on the validation that applies to every step of production until release of the product. FDA Guidelines will be used as a matter of example and will serve as a template based upon which students will develop validation protocols and use their critical thinking to determine the quality of a validation report.
Prerequisite: NONE
CLS 590
Writing a Research Proposal
The student selects a project of choice from a list of projects determined by a faculty member in a selected area of interest. The student should plan, write a proposal and submit a written report, present and defend the proposal. Laboratory experiments are not required.
Prerequisite: Approval of advisor
CLS 593
Pharmaceutical Quality Control
The course will make the students become aware of the up-to-date regulations applied to the production of active pharmaceutical ingredients in the pharmaceutical field. Manufacturing methods, pharmaceutical laboratory testing, chemistry manufacturing and control, labeling and product specification are among the aspects included in the course curriculum. To complete the information, troubleshooting techniques of various pharmaceutical products will be used as examples.
Prerequisite: NONE
CLS579L
Applied Toxicology Laboratory
This course covers the application of different methods and analytical techniques including Mass Spectrometry, Gas and Liquid Chromatography, UV Visible and AAS equipment. Students can learn the principle of these techniques and try to identify and monitor their various aspects.
Prerequisite: NONE
CLS583L
Forensic Chemistry Laboratory
This course covers the applications of wet chemistry techniques in the field of Forensic science: TLC, Color Test, Extraction Method, as well as the analysis and monitoring of controlled substances.
Prerequisite: NONE
CLS585L
Forensic Toxicology Laboratory
This laboratory course will address practical aspects in the toxicological testing methods of bodily fluid samples or tissue samples during the identification of toxic products. Another outcome of the course consists in becoming familiar with the determination of the level of contribution of a given substance to the intoxication or lethality of the body contaminated.
Prerequisite: NONE

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